The paper is going to handle three main religions common in the world mainly Christianity, Islam, and Buddhism. ChristianityDifferent geographical regions have diverse cultures and beliefs which are characterized as conflicting, in harmony or even with little interaction. Religion and science explain the natural laws and the universe using different methodologies. Science is mainly based on empiricism, reasoning, and evidence. Empiricism is a philosophical view that knowledge is and should always be based on experience. Empiricism is taken to be a fundamental starting point of science inclusive of the invention in religion. Scientific empiricism has the assumption that the scientists are independent, impartial, and completely unrelated to the phenomena under investigation. In contrast, religion is based on sacredness, revelation, and faith. Religion is argued to support its facts by use of supernatural powers that are hard to investigate in that they are not part of nature. Religious investigators have difficulties in their investigations in that during the research. they defend their religion instead of explaining the problem under study. In the United States, acceptance of the scientific facts such as natural selection especially in the line of human beings has been influenced by religion so much showing that religion and sciences are in a fight. However, the National Academy of Sciences has documented some facts that proofs of evolution are in accordance and compatible with some religious groups (NAS, 2008).According to Archbishop Habgood John, science is descriptive while religion is prescriptive. Schilling and Coulson claimed that religion and science are related so much in that both revolve around a three-fold structure of experience, theoretical interpretation, and finally the practical application of the new idea. Coulson continued to argue that the fields of science just like religion brings it facts by creative imagination but not from mere figures (Brandt-Rauf, 2006).