Since social factors also impact the health outcomes, nurses who are caring for postpartum patients will also have to take into account, the cultural aspects of care. This study proposes to examine the perspective of nurses’ duties in postpartum depression and how they can promote health outcomes through the application of Leininger’s culture theory.The birth of a child is associated with dramatic hormonal shifts. During the term of a pregnancy, the levels of endogenous glucocorticoids and estrogens in the body increase. however after the delivery of the child, the level of these hormones suddenly plummets, which causes a temporary hypoactivation in the hypothalamic-pituitary axis, which lasts for several weeks. As Cizza et al (1997) have demonstrated, this suppression of the hypothalamic-pituitary axis tends to be much more severe and lasts for a much longer period in women who are suffering from postpartum depression. While the extent of the hormonal impact does contribute to postpartum depression,Several studies have shown that a correlation exists between postpartum depression and the lack of social support. According to Hagen (2001), new mothers may tend to suffer from postpartum depression when they feel that they do not have adequate levels of social support. they may adapt by experiencing postpartum depression where they feel emotionally or financially disinvested in their infants. Some of the ante-natal risk factors which have been seen to be conducive towards the development of postpartum depression include experiencing depression or anxiety during pregnancy, a previous history of stress, lack of social support, low levels of self-esteem, low socio-economic status, single marital status or a poor relationship with one’s partner. (Stewart et al, 2004). Postpartum depression could have a potentially detrimental effect on infants because of the children of such mothers.