The concepts of cybernetics, when combined with the digital computers being created at that time, led Wiener to draw some insightful ethical conclusions. He perceptively foresaw innovative social and ethical consequences.In this new century, the global economy has entered an Information Technology era in which globalization and internet-based communication network have forced all large enterprises and companies to inevitably face the challenge of multiple venture management, including production management, strategic management, and capital management. (Ashby, 1956) The common essence for these enterprises is the uncertainty of management outcome. That is the reason why the manager cannot find a long-term and changeless way for fluctuating business environment and management objects. The theory of opportunity cybernetics and decision harmonizing in thispaper is designated to overcome the difficulties of modern enterprises with multiple venture management. In the following, we will introduce several exceptional phenomena that affect multiple venture management in the competitive global market. Then, we will outline the basic concepts and modeling of opportunity cybernetics and decision-harmonizing theory. Finally, an example of General Electric Company is shown to illustrate the practice of this theory in the real world.The science of cybernetics emerged during the 1940s as a part of the systems thinking movement. Norbert Wiener was the founding driver of contemporary cybernetics, working primarily on mechanical systems. Others have subsequently developed his work extensively in the modern field of robotics. Wiener’s group was interdisciplinary, bringing together mathematicians, biologists, operational researchers and physicists in a groundbreaking approach to developing a unified science for solving complex problems. Stafford Beer has for nearly forty years led the development of cybernetics in the study of organizations.